REVIEW article
Front. Endocrinol.
Sec. Diabetes: Molecular Mechanisms
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1589695
This article is part of the Research TopicNew Insights on Vascular and Metabolic Diabetic ComplicationsView all 13 articles
Mechanisms and Therapeutics of Insulin Signaling Transduction Genes in Diabetic Cardiomyopathy: A Comprehensive Updated Review
Provisionally accepted
- 1The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
- 2Southwest Medical University, Luzhou, Sichuan, China
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Diabetic cardiomyopathy (DCM), a complication of type 2 diabetes mellitus (T2DM), is closely associated with key genes in the insulin signaling pathway. Insulin regulates cellular metabolism and growth under normal conditions by activating downstream signaling pathways through its receptors. Nonetheless, insulin resistance, which compromises the insulin signaling pathway and impairs cardiovascular system performance, is common in individuals with T2DM. The key insulin signaling genes include IRS1, IRS2, PIK3R1, and GLUT4 play important roles in insulin receptor signaling, PI3K complex assembly, and glucose transport, respectively. Mutations or abnormal expression of these genes may lead to disorders in the insulin signaling pathway, affecting the normal regulation of glucose metabolism and impairment of myocardial function, thereby promoting the development of DCM. This review delves into the specific roles of these genes in the pathogenic mechanisms and treatment of DCM, with the aim of providing scientific evidence and guidance for future research endeavors.
Keywords: Diabetic cardiomyopathy, Heart Failure, insulin signaling, gene, Treatment
Received: 07 Mar 2025; Accepted: 25 Jun 2025.
Copyright: © 2025 He, Yang, He, Wang, Li, Yuan and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ping Yuan, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China
Chunhong Li, Southwest Medical University, Luzhou, Sichuan, China
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