ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1591652
The Association between Pancreatic Diseases and Pancreatic Fat Content: A Cross-Sectional Study from the UK Biobank
Provisionally accepted
- 1Affiliated Hospital of Yangzhou University, Yangzhou, China
- 2Yangzhou University, Yangzhou, Jiangsu Province, China
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Objective: Many researches have demonstrated an association between intra-pancreatic fat deposition (IPFD) and several pancreatic pathological conditions, including pancreatitis, pancreatic cancer, and type 2 diabetes mellitus (T2DM). The aim of this study is to investigate the influence of pancreatic diseases on the accumulation of pancreatic fat, to further explore which kind of pancreatic disease is significant, and to find out the possible mediating factors. Methods: A cross-sectional study based on the UK Biobank (UKB) data categorized participants by pancreatic disease status and collated relevant information. IPFD was measured using MRI in combination with a deep learning-based organ segmentation model, nnUNet. Linear regression models and mediation analysis were employed to explore the association between pancreatic diseases and IPFD. Results: Among 61 088 participants, those with pancreatic diseases exhibited higher IPFD than those without (pancreatic endocrine diseases: 11.72% vs 7.94%, P<0.001; pancreatic exocrine diseases: 9.44% vs 8.03%, P<0.001). After adjusting for multiple variables, a positive association between pancreatic endocrine diseases (particularly T2DM) and IPFD persisted, but not for pancreatic exocrine diseases. Obesity and dyslipidemia partially explained the relationship between T2DM and IPFD. Conclusion: Pancreatic exocrine disorders are not associated with an increased risk of IPFD, whereas pancreatic endocrine disorders, particularly T2DM, may exhibit a positive relationship. However, the possibility of reverse causation cannot be discounted.
Keywords: Intra-pancreatic fat deposition, Pancreatic Diseases, type 2 diabetes mellitus, UK Biobank, Mediation analysis
Received: 11 Mar 2025; Accepted: 19 May 2025.
Copyright: © 2025 Gao, Dong, Shi, Yang, Xiao, Chen, Lu and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoping Yu, Affiliated Hospital of Yangzhou University, Yangzhou, China
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