ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1592618
This article is part of the Research TopicPrevention and Treatment Advancements in Diabetic RetinopathyView all 12 articles
The influence of renal function on surgical outcomes of vitrectomy in patients with proliferative diabetic retinopathy
Provisionally accepted
- Department of ophthalmology, Xinqiao Hospital, Army Medical University, Chongqing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Purpose: To investigate the influence of renal function on surgical outcomes of vitrectomy in patients with proliferative diabetic retinopathy (PDR).Methods: A secondary analysis was conducted on data from a retrospective cohort study.Results: A total of 128 eyes with PDR that underwent pars plana vitrectomy (PPV) and were followed up for at least 2 years were enrolled, including 65 eyes in the impaired renal function (IRF) group and 63 eyes in the normal renal function (NRF) group. No significant between-group differences were observed in the proportion of cataract surgery (p = 0.722), intraoperative retinal photocoagulation (p = 0.476), gas tamponade (p = 0.932), silicone oil tamponade (p = 0.254), retinal dialysis and/or iatrogenic retinal breaks (p = 0.447), and 23-or 25-gauge (G) microincision vitreous surgery (MIVS) (p = 0.160). Similarly, intergroup comparisons showed no significant differences in the proportion of reoperation (p = 0.883), postoperative vitreous hemorrhage (VH) and/or retinal detachment (RD) (p = 0.919), postoperative neovascular glaucoma (NVG) (p = 0.600) and postoperative diabetic macular edema (DME) (p = 0.794). Notably, the IRF group had worse baseline best corrected visual acuity (BCVA) (p = 0.039) and showed greater BCVA improvement at 3 months (p = 0.008), 6 months (p = 0.047), 1 year (p = 0.007), 2 years (p = 0.003), 3 years (p = 0.009) and 4 years (p = 0.024) after surgery. However, there was no significant difference in postoperative BCVA between the two groups at each follow-up time (all p > 0.05).Conclusions: Renal insufficiency does not adversely affect the surgical outcomes of PPV in patients with PDR.
Keywords: Diabetes Mellitus, proliferative diabetic retinopathy, Renal function, surgical outcomes, Vitrectomy
Received: 12 Mar 2025; Accepted: 24 Jun 2025.
Copyright: © 2025 Yuan, Yang, Fan, Chen, Zou and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Rongdi Yuan, Department of ophthalmology, Xinqiao Hospital, Army Medical University, Chongqing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.