ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Thyroid Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1594561
Safety enhancement of improved hydrodissection for microwave ablation in lymph node metastasis from papillary thyroid carcinoma: a comparative study
Provisionally accepted
- China-Japan Friendship Hospital, Beijing, China
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This study aims to evaluate the efficacy and safety of an improved hydrodissection technique based on the perilymph-nodal space (PLNS), when applied during microwave ablation for treating lymph node metastases (LNM) arising from papillary thyroid carcinoma (PTC).Methods A retrospective analysis was conducted on data from 266 patients (95 males, 171 females; mean age 41.3 ± 14.0 years [range 16-88]) who underwent MWA for LNM. Of these, 142 patients received traditional hydrodissection (traditional group), while 124 underwent improved hydrodissection. Safety enhancement outcomes were assessed by comparing complication rates between the two groups. Additionally, the features of the hydrodissected fascial spaces, complications, and follow-up results were documented.All patients underwent successful hydrodissection as planned. The improved hydrodissection group demonstrated a lower incidence of hoarseness compared to the traditional group (4.8% vs. 8.4%, p > 0.05).Notably, in cases of region VI, the improved technique significantly reduced hoarseness incidence (7.5% vs. 25%, p = 0.006). Additionally, median recovery time for hoarseness was shorter in the improved method (3 vs. 6 months, p < 0.05). During follow-up, neither group exhibited local recurrence. The tumor disappearance rates were comparable between groups (75.4% vs. 65.3%, p > 0.05).The PLNS-based improved hydrodissection technique showed enhanced safety over traditional hydrodissection during MWA for LNM, especially for region VI lesions.
Keywords: lymph node metastasis, Papillary thyroid cancer, Hydrodissection, Microwave ablation, Fascial space
Received: 16 Mar 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Wu, wei, Zhao, Cao, Li, Peng, Li and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ming-an Yu, China-Japan Friendship Hospital, Beijing, China
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