SYSTEMATIC REVIEW article
Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1595232
This article is part of the Research TopicGenetic Implications in Male Infertility and Advances in Assisted Reproductive Technologies: Towards New Diagnostic and Therapeutic PerspectivesView all 3 articles
Impact of the PPOS Protocol on Euploidy Embryo Rates and Reproductive Outcomes in Preimplantation Genetic Testing Cycles:A Systematic Review
Provisionally accepted
- Chengdu Women and Children’s Central Hospital, Chengdu, Sichuan Province, China
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The success of assisted reproductive technology (ART) relies on the quality of embryos, particularly the euploid status, which is influenced by controlled ovarian hyperstimulation (COH) protocols. In recent years, the progesterone-primed ovarian stimulation (PPOS) protocol has gained popularity due to its potential benefits. However, the impact of PPOS on euploid embryo rates (EER) and reproductive outcomes remains incompletely understood. Therefore, we conducted this review to comprehensively assess this impact by comparing the PPOS with conventional COH protocols in PGT cycles. The results revealed that the PPOS protocol demonstrated comparable EER and reproductive outcomes to conventional COH protocols in the general population. Among patients with a good prognosis, EER and associated reproductive outcomes with PPOS may be less favorable. However, in individuals with a poor prognosis, PPOS showed comparable or even superior outcomes. Additionally, the timing of cycle initiation, whether in the follicular or luteal phase, had no significant impact on clinical outcomes in patients with diverse ovarian responses.
Keywords: Progesterone-Primed Ovarian Stimulation protocol, Preimplantation GeneticTesting, Euploidy Embryo Rate, Reproductive outcomes, Controlled OvarianHyperstimulation
Received: 17 Mar 2025; Accepted: 19 Aug 2025.
Copyright: © 2025 Mei, Wang, Kuang, Lin and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yonghong Lin, Chengdu Women and Children’s Central Hospital, Chengdu, Sichuan Province, China
Fang Wang, Chengdu Women and Children’s Central Hospital, Chengdu, Sichuan Province, China
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