ORIGINAL RESEARCH article

Front. Endocrinol.

Sec. Clinical Diabetes

Volume 16 - 2025 | doi: 10.3389/fendo.2025.1595584

Evaluating the Impact of First and Last Trimester HbA1c on Neonatal Weight and Placental Mediation in T1DM

Provisionally accepted
Mohammed BashirMohammed Bashir1*Adeel KhanAdeel Khan2Fateen AtaFateen Ata1Manar ElhassanManar Elhassan3Fatin EltaherFatin Eltaher4Gernot DesoyeGernot Desoye5Justin C KonjeJustin C Konje6,7Abdul Abou-SamraAbdul Abou-Samra1
  • 1Qatar Metabolic Institute, Hamad Medical Corporation, Doha, Qatar
  • 2Cleveland Clinic Akron General, Akron, Ohio, United States
  • 3Department of Public Health, College of Health Sciences, Qatar University, Doha, Qatar
  • 4Women’s Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar
  • 5Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Styria, Austria
  • 6Department of Obstetrics and Gynecology, Feto Maternal Centre, Doha, Al Markhiya, Qatar, Doha, Qatar
  • 7Weill Cornell Medicine- Qatar, Ar-Rayyan, Qatar

The final, formatted version of the article will be published soon.

Select one of your emails

You have multiple emails registered with Frontiers:

Notify me on publication

Please enter your email address:

If you already have an account, please login

You don't have a Frontiers account ? You can register here

weight and the role of the placenta are not fully understood.Objective: This study explores the relationship between glycaemic control, neonatal weight, and placental weight.Design: A retrospective observational longitudinal study of pregnant women with T1DM.The study included 265 women with T1D. The target for the first A1c was set at ≤ 7.0%, while the target for the last A1c was ≤ 6.5%. The cohort was divided into four groups based on whether they achieved their target A1c (T) or had levels higher than the target (H) at each end. These groups were classified as Target-Target (T-T), Target-High (T-H), High-Target (H-T), and High-High (H-H). For the secondary objective, we included 154 women for whom placental weight data were available.

Keywords: Type 1 diabetes mellitus, Pregnancy, Placenta, mediatation, Neonatal weight

Received: 18 Mar 2025; Accepted: 19 May 2025.

Copyright: © 2025 Bashir, Khan, Ata, Elhassan, Eltaher, Desoye, Konje and Abou-Samra. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mohammed Bashir, Qatar Metabolic Institute, Hamad Medical Corporation, Doha, Qatar

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material