ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1597427
Association of inflammatory index with the severity of disease in patients with acute myocarditis: A retrospective observational study
Provisionally accepted
- Center for Cardiovascular Medicine, First Affiliated Hospital of Jilin University, Changchun, China
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This research aimed to investigate the association between neutrophil-percentage-to-albumin ratio (NPAR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) with disease severity in patients diagnosed with acute myocarditis. Methods A total of 185 patients were diagnosed with acute myocarditis at the First Hospital of Jilin University between 2018 and 2024. The related values of NPAR, SII, SIRI, and AISI were computed based on the pertinent blood indices that were acquired within 12 hours of admission. The best cut-off values for NPAR, SII, SIRI,and AISI, as well as their associated sensitivity and specificity, were determined using ROC curve analysis in order to assess their predictive usefulness for poor prognosis upon admission.Patients with fulminant myocarditis exhibited significantly higher NPAR, SII, SIRI, and AISI values compared to those with mild myocarditis. Spearman correlation analysis revealed significant associations between these inflammatory indices and NYHA scores at admission (r = 0.370, 0.296, 0.284, and 0.246, respectively; P < 0.01). Multivariate logistic regression analysis identified high NPAR (OR: 5.44 95%,
Keywords: Systemic inflammatory index, systemic immune-inflammation index, Acute myocarditis, NPAR, SII, SIRI, AISI;
Received: 10 Apr 2025; Accepted: 29 Jul 2025.
Copyright: © 2025 Wang, Xu, 国, Tian, Guo, Chu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yushi Wang, Center for Cardiovascular Medicine, First Affiliated Hospital of Jilin University, Changchun, China
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