ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1598998
IVF/ICSI treatment for patients with diminished ovarian reserve with or without Kuntai capsule pretreatment: a retrospective cohort study stratified by a controlled ovarian stimulation regimen
Provisionally accepted
- 1Other, nancan, China
- 2jiangxi Maternal and Child Health Hospital, Nanchang, China, nanchang, China
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Background: Kuntai capsules, a traditional Chinese medicine, are speculated to improve the treatment outcomes of patients with ovarian reserve dysfunction (DOR), but existing evidence is limited. Objective: To investigate the effects of Kuntai capsule pretreatment on the IVF/ICSI treatment outcomes of DOR patients with different ovarian stimulation regimens (PPOS, antagonists, and microstimulation). Method: A retrospective cohort study design was used to include 7271 DOR patients who underwent IVF/ICSI between January 2015 and February 2025. After baseline data were balanced through propensity score matching (PSM), 1474 patients were ultimately included. The number of retrieved eggs, laboratory indicators, and clinical outcomes were compared between the group pretreated with Kuntai capsules and the group not pretreated with Kuntai capsules under three ovarian stimulation regimens, and confounding factors were controlled via a generalized estimating equation (GEE) model. Result: In the PPOS regimen, the number of retrieved eggs (without kuntai: 2.
Keywords: diminished ovarian reserve, Kuntai Capsule, Infertility, Clinical pregnancy, antagonists
Received: 24 Mar 2025; Accepted: 20 May 2025.
Copyright: © 2025 Wan, yu, wu, huang and Tan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jun Tan, jiangxi Maternal and Child Health Hospital, Nanchang, China, nanchang, China
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