ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1599158
Serum uric acid to creatinine ratio and long-term target vessel events in diabetes patients undergoing PCI with drug-eluting stents implantation: A retrospective study
Provisionally accepted
- 1Changzhi People's Hospital, Changzhi, Shanxi Province, China
- 2Changzhi Medical College, Changzhi, Shanxi Province, China
- 3Jilin University, Changchun, Hebei Province, China
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Aim: This study aimed to investigate the association between the serum uric acid to creatinine ratio (SUA/Cr) and long-term target vessel events (TVEs) in diabetes mellitus (DM) patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES).Methods: From July 2009 to August 2011, a total of 2533 patients with coronary heart disease (CHD) who underwent PCI with DES implantation were enrolled to evaluate the relationship between the SUA/Cr and TVEs during a median follow-up of 29.8 months. Multivariable logistic regression and restricted cubic spline analyses were performed, and subgroup analyses were conducted to explore potential effect modifiers.Results: The TVEs were significantly associated with previous male gender (OR=1.58, 95%CI: 1.07~2.32, p=0.021), PCI (OR=3.58, 95% CI: 2.27~5.67, p<0.001),previous stroke(OR=2.19,95%CI:1.24~3.89,p=0.007),triglyceride(OR=1.15, 95%CI:1.06~1.26, p=0.002), length of stent (OR=1.01, 95%CI:1~1.01, p<0.001), and diameter of stent (OR=0.62,95%CI:0.41~0.92,p=0.019). In DM patients, Multivariable logistic regression analyses revealed that higher SUA/Cr was independently associated with a reduced risk of TVEs (adjusted OR=0.72, 95% CI: 0.53–0.97, p=0.031). Restricted cubic spline analysis confirmed a linear inverse relationship between SUA/Cr and TVEs (p for non-linearity=0.782). Subgroup analyses revealed stronger protective effects in non-smokers and non-ST elevation acute coronary syndrome (NSTE-ACS) patients within the DM cohort.Conclusion: A higher SUA/Cr is independently associated with a reduced risk of TVEs in DM patients undergoing PCI with DES. SUA/Cr holds promise as a potential prognostic biomarker for risk stratification in DM patients undergoing PCI.
Keywords: Diabetes Mellitus, coronary heart disease, Target vessel events, serum uric acid to creatinine ratio, Percutaneous Coronary Intervention
Received: 24 Mar 2025; Accepted: 02 Jun 2025.
Copyright: © 2025 Cui, Wang, Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ruihua Wang, Changzhi People's Hospital, Changzhi, Shanxi Province, China
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