CASE REPORT article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1599546
This article is part of the Research TopicCase Reports in Autoimmune and Autoinflammatory Disorders: Volume IIView all 11 articles
A case report of familial type 2 diabetes mellitus combined with hypothyroidism and multiple autoimmune diseases
Provisionally accepted- Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China
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Gene mutations in Janus kinase/signal transducer and activator of transcription signaling pathway can promote the occurrence of type 2 diabetes mellitus and autoimmune diseases. We report two type 2 diabetes mellitus patients (mother and her adult son) with concomitant Hashimoto ' s thyroiditis and autoimmune diseases. The son was diagnosed with systemic sclerosis and antiphospholipid syndrome, while the mother was diagnosed with primary biliary cholangitis. Both diagnoses occurred simultaneously. These cases highlight that in clinical practice, careful symptom assessment, thorough history-taking, standardized physical examination, and obtaining a detailed family history are important. This reduces misdiagnosis and missed diagnosis rates, enabling early diagnosis and treatment, thereby improving patient outcomes. While genetic testing is not performed in these two patients, this represents a potential direction for future research.
Keywords: type 2 diabetes, Hypothyroidism, Hashimotos thyroiditis, autoimmune disease, case report
Received: 25 Mar 2025; Accepted: 11 Jul 2025.
Copyright: © 2025 Su, Yang, Jiang, Lai and Qu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yang Yang, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China
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