MINI REVIEW article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1599660
This article is part of the Research TopicPathophysiology of Diabetic Kidney DiseaseView all 9 articles
Kidney Transplantation with Preformed Diabetic Nephropathy Kidney: Review of Pathological Changes and Clinical Outcomes
Provisionally accepted
- 1Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
- 2First Naval Hospital of Southern Theater Command, Zhanjiang, Guangdong Province, China
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Introduction: Kidney transplantation from expanded-criteria donors represents an effective approach to alleviate organ shortages. The feasibility for transplantation of donor kidneys with preformed diabetic nephropathy (DN) has not been extensively investigated. Search strategy: We performed a literature review to explore the pathological changes and clinical outcomes of kidney transplantation using preformed DN kidney. A systematic and comprehensive search was conducted from the inception to June 13, 2024. Results: Data from eight articles encompassing 103 cases were included for analysis. The pooled proportions of stable, progressive, and reversed DN-related pathological change were 0.66 (95% CI 0.56-0.77, I 2 = 21.77%), 0.27 (95% CI 0.18-0.36, I 2 = 10.04%) and 0.05 (95% CI 0.01-0.10, I 2 = 0.00%), respectively. Eight-six cases were divided into post-transplant hyperglycemia group and normal post-transplant blood glucose group to evaluate the effect of posttransplant hyperglycemia on DN pathology, indicating the normal post-transplant blood glucose group had higher proportions of stable and reversed pathological states. Most cases achieved a graft survival rate of more than 80% at around five years post-transplant. Conclusion: A majority of transplantations use donor kidneys with preformed DN exhibit acceptable renal pathological changes and graft survival. However, post-transplant hyperglycemia may adversely affect the pathological progression of the kidneys, particularly in cases with long-term follow-up.
Keywords: diabetic nephropathy, preformed diabetic nephropathy, Donor, Transplantation, post-transplant hyperglycemia
Received: 25 Mar 2025; Accepted: 11 Jun 2025.
Copyright: © 2025 Li, Wang, Chen, Tang, Zhang and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Maozhi Tang, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
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