REVIEW article
Front. Endocrinol.
Sec. Pituitary Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1600559
Recent advances in anterior pituitary hormones and Metabolic-Associated Fatty Liver Disease
Provisionally accepted
- 1Shandong First Medical University, Tai'an, China
- 2Jinan Central Hospital, Jinan, Shandong Province, China
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The classical theory of the pituitary-target gland axis suggests that the hormones secreted by the pituitary gland only regulate the synthesis and secretion of target gland hormones, while the target gland hormones act on the tissues of the body to achieve biological functions.However, recent studies have shown that anterior pituitary hormone receptors are also expressed on the surface of hepatocytes. This suggests that anterior pituitary hormones may act directly on hepatocytes to exert regulatory effects independent of target hormones. The review systematically summarizes the mechanisms and effects of thyroidstimulating hormone (TSH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), adrenocorticotropic hormone (ACTH), , growth hormone (GH), and melanocyte-stimulating hormones (MSH) on liver metabolism and their roles in the pathogenesis of Metabolic-Associated Fatty Liver Disease (MAFLD). It is hoped that this
Keywords: MAFLD, Anterior pituitary hormone, metabolic mechanisms signal transduction, Lipid metabilism, metabolism dysfunction
Received: 26 Mar 2025; Accepted: 11 Jun 2025.
Copyright: © 2025 Liu, Long, Liu and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Changqing Liu, Shandong First Medical University, Tai'an, China
Yongfeng Song, Jinan Central Hospital, Jinan, 250000, Shandong Province, China
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