ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1601897
The Effect of Surgical Cure of Primary Hyperparathyroidism on Cardiac Electrical Activity. A Cross-Sectional Study
Provisionally accepted
- Medical University of Gdansk, Gdańsk, Poland
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Cardiovascular complications are not assessed routinely in the management of primary hyperparathyroidism (pHPT), nor do they constitute indications for surgical treatment of this disorder.Research concerning the effects on cardiac electrical activity in PHPT is scarce.In the current study, 45 consecutive pHPT patients with hypercalcaemia and elevated parathyroid hormone levels were assessed clinically, biochemically and by 24-h ECG monitoring before, one and six months after curative parathyroidectomy (PTX).There were 41 female and four male subjects, their mean age was 54.6 ±14.6 years. 20 patients were normotensive and 25 had previously or newly diagnosed hypertension. Patients without hypertension compared to the hypertensive ones had lower BMI: 23.2 (20.3-25.4) versus 26.7 (24.8-28.4), higher total calcium: 11.9 ±0.8 versus 11.3 ±0.9 mg/dL, and shorter QTc: 418 ±17 versus 436 ±17 ms, p<0.001. Before surgery, Ca and PTH correlated negatively with QTc. Upon curative PTX, the median number of supraventricular premature beats (SVPBs) and ventricular premature beats (VPBs) decreased significantly, which was paralleled by a 37% decrease in the prevalence of clinically significant SVPBs (>76 per 24h), and a 29% decrease in the number of patients with more than 3 VPBs/24h six months after surgery. QTc increased from 428 ±19 before to 441 ±17 ms after PTX. The change in the median number of SVPBs and VPBs was comparable between patients with versus without HT.Curative PTX normalizes QTc, reduces supraventricular and ventricular extrasystoles in patients with hypercalcaemic pHPT.
Keywords: primary hyperparathyroidism, Parathyroidectomy, Hypertension, Premature cardiac complexes, Electrocardiography
Received: 28 Mar 2025; Accepted: 02 Jul 2025.
Copyright: © 2025 Kmieć, Karwacka-Bujak, Bohdan, Świątkowska-Stodulska and Sworczak. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Izabela Maria Karwacka-Bujak, Medical University of Gdansk, Gdańsk, Poland
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.