REVIEW article
Front. Endocrinol.
Sec. Diabetes: Molecular Mechanisms
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1606816
Complementary Efficacy and Molecular Insights of Polygonati Rhizoma Polysaccharide for Glycemic and Lipid Abnormalities in Type 2 Diabetes Mellitus: A Comprehensive Review
Provisionally accepted
- 1College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
- 2Henan Key Laboratory of Chinese Medicine Resources and Chemistry, Zhengzhou, Henan Province, China
- 3Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou, China
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Background: T2DM is a global health challenge characterized by insulin resistance and impaired glucose metabolism. Natural products, such as polysaccharides from medicinal plants, are increasingly explored for their potential in managing T2DM with fewer side effects compared to conventional drugs. Aim: This review aims to comprehensively evaluate the effects of Polygonati Rhizoma Polysaccharide (PRP) on glucose and lipid metabolism in T2DM and elucidate its underlying molecular mechanisms. Introduction: In recent years, numerous scientific studies have demonstrated that Polygonati Rhizoma Polysaccharide (PRP) exerts beneficial effects on type 2 diabetes mellitus (T2DM), enhancing both glucose and lipid metabolism. This article provides a comprehensive review of the impact of PRP on T2DM influencing glucose and lipid metabolism and elucidates the underlying molecular mechanisms. Methods: A comprehensive literature search was conducted across electronic databases including PubMed, Web of Science, Wanfang Database, and China National Knowledge Infrastructure (CNKI). The search encompassed publications from June 2010 to June 2025, representing a 15-year period. Titles and abstracts were systematically screened for relevance, after which full-text articles meeting the inclusion criteria within this timeframe were selected for analysis. Discussion: Current evidence indicates that PRP can ameliorate T2DM alongside improving glucose and lipid profiles; this effect is predominantly linked to its modulation of the PI3K/AKT signaling pathway. Furthermore, its lipid-lowering properties are associated with regulation of gut microbiota, enhancement of intestinal barrier function, promotion of short-chain fatty acids (SCFAs) production, activation of G Protein-Coupled Receptors 41 and 43 (GPCR41 and 43), as well as inhibition of the TLR4/MyD88/NF-κB signaling cascade. Conclusion: Polygonati Rhizoma Polysaccharide can obviously improve the hyperglycemia and hyperlipidemia caused by T2DM, and has certain anti-inflammatory and antioxidant effects.
Keywords: Polygonati rhizoma polysaccharide, type 2 diabetes, Blood Glucose, Blood lipids, mechanisms, Animal Models
Received: 06 Apr 2025; Accepted: 25 Aug 2025.
Copyright: © 2025 Ma, Xu, Hou, Zhang, Cui and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yongxia Cui, College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
Suiqing Chen, College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
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