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ORIGINAL RESEARCH article

Front. Endocrinol.

Sec. Cardiovascular Endocrinology

Volume 16 - 2025 | doi: 10.3389/fendo.2025.1606819

Impact of Stress Hyperglycemia Ratio on Acute Kidney Injury and Mortality in Patients with Cardiogenic Shock: A Retrospective Analysis

Provisionally accepted
An  CaiAn Cai1Liqin  ZhuangLiqin Zhuang1Min  HeMin He2Song  HuangSong Huang1Jinying  TongJinying Tong1*
  • 1Department of Cardiovascular Medicine, People’s Hospital of Yingtan City, Yingtan, China
  • 2Department of Cardiology, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi Zhuang Region, China

The final, formatted version of the article will be published soon.

Aims This study investigated the predictive value of the stress hyperglycemia ratio (SHR) for acute kidney injury (AKI) and mortality in cardiogenic shock (CS). Methods A retrospective analysis was conducted on patients with CS from the Medical Information Mart for Intensive Care IV database based on SHR values. The primary outcome was AKI incidence, with in-hospital and 90-day mortality as secondary outcomes in the subgroup with AKI. Logistic regression assessed the relationship between SHR and AKI as well as in-hospital mortality, while Cox regression was employed to evaluate 90-day mortality. Restricted cubic spline curves were utilized to explore nonlinear associations. Results Among 378 patients with CS, 56.9% developed AKI. Elevated SHR was associated with a higher risk of AKI (OR 2.58, 95% CI 1.44–4.81). In the AKI subgroup, SHR exhibited a U-shaped relationship with mortality (P for non-linearity < 0.05). An SHR above 1.26 was linked to increased in-hospital (OR 2.74, 95% CI 1.35–5.80) and 90-day mortality (HR 2.84, 95% CI 1.95–4.13). Conclusions SHR is independently associated with both AKI and mortality in CS. A U-shaped curve suggests that optimal glycemic control may improve patient outcomes. Prospective studies are needed to validate these findings and further investigate SHR as a prognostic marker.

Keywords: Stress hyperglycemia ratio, Cardiogenic shock, Intensive Care Unit, Acute Kidney Injury, Mortality

Received: 06 Apr 2025; Accepted: 07 Aug 2025.

Copyright: © 2025 Cai, Zhuang, He, Huang and Tong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Jinying Tong, Department of Cardiovascular Medicine, People’s Hospital of Yingtan City, Yingtan, China

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