ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1607497
The role of metabolic score of visceral fat in prediction of atrial fibrillation recurrence risk after catheter ablation
Provisionally accepted
Yazhe Ma1*
Xiaolong Gao1Jianying Sun1Xiaohui Kuang1Xi Zhang1Feiyu Wei1Tao Ma1Yanju Cui1Jia Guo1Peng Wu1Jiangwen Liu2Jie Fan1- 1The First People’s Hospital of Yunnan Province, Kunming, China
- 2Tianjin Medical University, Tianjin, Tianjin Municipality, China
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Background：Previous studies show that visceral fat tissue (VAT) play an important role in atrial fibrillation (AF). The metabolic score of visceral fat (METS-VF), a new surrogate to estimate VAT, is associated with cardiovascular mortality risk.Hypothesis: This study aimed to investigate the association between Mets-VF and the risk of AF recurrence after catheter ablation. Methods: 478 consecutive patients underwent catheter ablation were obtained and used to assess the relationship between METS-VF and the risk of AF recurrence. Cox proportional hazards models were used to assess the association between METS-VF and AF recurrence, with results expressed as hazard ratios (HR) and 95% confidence intervals (CI). Restricted cubic spline (RCS) was used to assessed the linear relationship between METS-VF and the AF recurrence risk.Results: A total of 112(23.4%) patients experienced AF recurrence during 18.0 ± 9.6 months follow-up. Kaplan-Meier analysis showed that patients in the highest METS-VF quartile had a significantly higher recurrence rate compared to the lower quartiles (log-rank P = 0.021). In the multivariable Cox model, patients in the highest METS-VF quartile (Q4) had a 2.22-fold higher risk of AF recurrence compared to those in the lowest quartile (Q1) (HR = 2.22, 95% CI: 1.20-4.12, P < 0.01). Restricted cubic spline (RCS) shows a dose-response relationship between METS-VF and AF recurrence.Conclusions: METS-VF was positively associated with the elevated AF recurrence risk. Our findings show that the METS-VF could be used to AF recurrence risk stratification.
Keywords: metabolic score of visceral fat, Atrial Fibrillation, Visceral obesity, Catheter Ablation, Independent risk factor
Received: 07 Apr 2025; Accepted: 07 Aug 2025.
Copyright: © 2025 Ma, Gao, Sun, Kuang, Zhang, Wei, Ma, Cui, Guo, Wu, Liu and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yazhe Ma, The First People’s Hospital of Yunnan Province, Kunming, China
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