REVIEW article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1607641
The Role of Mitochondrial Function in the Pathogenesis of Diabetes
Provisionally accepted
- Shaoxing City Women and Children Hospital, Shaoxing, China
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Diabetes mellitus is a chronic metabolic disease characterized by abnormally elevated blood sugar levels due to insulin deficiency or insulin resistance, ultimately leading to various serious complications. In this review, we highlighted the significance of mitochondrial functionality in diabetes, concentrating on elements such as mitochondrial energy metabolism, oxidative stress, and their interplay with insulin sensitivity. Mitochondria are essential organelles that are crucial for energy production and integral to cellular metabolic processes.Recent investigations have underscored the role of mitochondrial dysfunction in the advancement of diabetes, uncovering fundamental mechanisms that lead to insulin resistance and elevated blood glucose levels. Present study amalgamates insights from contemporary studies, emphasizing the criticality of mitochondrial integrity in the occurrence of diabetes and its promise as a target for therapeutic intervention. By clarifying these associations, we aspire to offer novel perspectives and pathways for the prevention and management of diabetes.
Keywords: Mitochondrial function (MF), Diabetes mellitus (DM), Energy Metabolism (EM), Oxidative stress (OS), insulin sensitivity (IS)
Received: 08 Apr 2025; Accepted: 08 Jul 2025.
Copyright: © 2025 Qin, Wang and Ding. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jinlong Ding, Shaoxing City Women and Children Hospital, Shaoxing, China
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