ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Renal Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1610140
Triglyceride-Glucose Index and Overactive Bladder Syndrome: evidence from the NHANES 2005-2018
Provisionally accepted
- 1Meizhou Academy of Medical Sciences, Meizhou, China
- 2Guangdong Medical University, Zhanjiang, Guangdong, China
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Introduction:The relationship between the triglyceride-glucose index (TyG) and overactive bladder (OAB) is unclear. The aim of this study was to investigate the possible association between the TyG index and OAB.Methods: National Health and Nutrition Examination Survey (NHANES) data from 2005-2018 were used. The association between TyG index and OAB was assessed using univariate and multivariate logistic regression models. In addition, restricted cubic spline curves were used to examine the dose-response relationship between TyG index and OAB risk. Subgroup analyses and interaction analyses were then performed to assess differences in associations between subgroups.Results: A total of 14,059 participants with 3325 patients with OAB were included. In the fully adjusted model, each unit increase in the TyG index was associated with a 1.18-fold increased risk of OAB (OR = 1.18; 95% CI: 1.11-1.26; p < 0.001) and a 1.32fold increased risk of OAB for Q4 compared to Q1 at the quartile level (OR = 1.32, 95% CI: 1.17-1.50, p < 0.001), RCS analysis showed a positive linear association between TyG index and OAB, and subgroup analysis showed that the association between TyG and OAB was more pronounced in individuals younger than 60 years and in women (p for interaction < 0.05).The results of this study suggest that TyG index is positively associated with OAB, and this association was more pronounced in younger age groups and in females.TyG index, as a simple and cost-effective metabolic marker, may provide a potential tool for early screening of OAB, especially in individuals with metabolic abnormalities that have not progressed to significant metabolic diseases.
Keywords: Overactive bladder syndrome, OAB, TyG index, Cross-sectional study, Risk Assessment, NHANES
Received: 11 Apr 2025; Accepted: 15 May 2025.
Copyright: © 2025 Baitong, Jiongming, Yueting and Nanhui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chen Baitong, Meizhou Academy of Medical Sciences, Meizhou, China
Chen Nanhui, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China
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