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MINI REVIEW article

Front. Endocrinol.

Sec. Bone Research

Volume 16 - 2025 | doi: 10.3389/fendo.2025.1611677

This article is part of the Research TopicVibratory Therapy: Impacts on Endocrine DisordersView all articles

Advances in Vibration Therapy for the Treatment of Osteoporosis

Provisionally accepted
Xueyan  LuXueyan Lu1Haoyang  DuanHaoyang Duan2*
  • 1Department of Rehabilitation, Tonghua People's Hospital, Tonghua, Jilin, China
  • 2Department of Rehabilitation Medicine, First Hospital of jilin University, Changchun, China

The final, formatted version of the article will be published soon.

Osteoporosis is a systemic skeletal disease characterized by reduced bone density and degeneration of bone microstructure. It is prevalent among postmenopausal women and elderly individuals.Current treatments face challenges such as drug side effects, low adherence, and comorbidities.Vibration therapy, as a non-invasive physical treatment, regulates bone metabolism through mechanical stress stimulation and is emerging as an important complementary strategy in the comprehensive management of osteoporosis. This article systematically reviews the mechanisms of action and clinical efficacy of vibration therapy. Studies indicate that vibration therapy activates osteoblast differentiation pathways (e.g., the Wnt/β-catenin signaling pathway) through lowfrequency mechanical vibrations, upregulates osteogenic markers (e.g., Runx2, BMP-2, OPG), and inhibits osteoclast activity, reducing the RANKL/OPG ratio to bidirectionally regulate bone metabolic balance. Further mechanistic studies on muscle dynamics show that vibration stimulation enhances muscle contractile force, promoting bone formation through mechanical loading. Clinical trials demonstrate that vibration therapy has potential in improving lumbar and hip bone density, enhancing bone biomechanical properties, and reducing fracture risk, particularly when combined with drugs such as bisphosphonates or teriparatide, showing synergistic effects. However, variability in therapeutic outcomes (e.g., insignificant improvement in trabecular structure) may be related to differences in vibration parameters (frequency, amplitude, acceleration), device types, and individual responses. The current advantages of vibration therapy lie in its ease of use, high safety, but its clinical application still lacks standardized parameter guidelines. Future research should establish individualized treatment protocols and a biological equivalent dose system through large-scale randomized controlled trials to promote the standardized development of this therapy.

Keywords: Vibration therapy1, osteoporosis2, bone density3, osteoblasts4, osteoclasts5, Mechanical stress6

Received: 22 Apr 2025; Accepted: 31 Jul 2025.

Copyright: © 2025 Lu and Duan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Haoyang Duan, Department of Rehabilitation Medicine, First Hospital of jilin University, Changchun, China

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