ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Thyroid Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1611963
Association between sensitivity to thyroid hormone and prognosis in septic patients: a retrospective cohort analysis
Provisionally accepted
Jia Wang
Yingbai Wang
Zihan Xu
Chuxun ChouJiaofeng XiangXizhi ZhangXuefei Hou
Suru Yue
Feng Chen
Shicai Ye
Jiayuan Wu*- Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China
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Sepsis is a life-threatening condition with significant endocrine dysfunction, particularly in thyroid hormone metabolism. However, the prognostic role of thyroid hormone sensitivity indices remains unclear. In this retrospective study of 2,391 sepsis patients, we utilized restricted cubic spline models, Cox proportional hazards models, and K-means clustering to assess the associations between thyroid hormones, sensitivity indices (FT3/FT4, TFQI, PTFQI, TSHI, TT4RI), and sepsis mortality. Our findings demonstrated that impaired thyroid hormone sensitivity is significantly associated with increased mortality in sepsis, suggesting their potential as biomarkers for risk stratification and personalized management.
Keywords: Sepsis, Thyroid Hormones, Thyroid hormone sensitivity indices, Cox proportional hazards model, K-Means clustering analysis
Received: 15 Apr 2025; Accepted: 11 Aug 2025.
Copyright: © 2025 Wang, Wang, Xu, Chou, Xiang, Zhang, Hou, Yue, Chen, Ye and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jiayuan Wu, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China
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