MINI REVIEW article
Front. Endocrinol.
Sec. Bone Research
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1612005
The roles of bone-muscle crosstalk in diseases not confined to the motor system
Provisionally accepted
- Harbin Medical University, Harbin, China
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The motor system determines body movement by taking advantage of anatomically connected bones and muscles. Moreover, as endocrine organs, bones and muscles produce osteokines and myokines to interact with each another. Furthermore, the interaction between bones and muscles is affected by other conditions, including chronical renal diseases, chronic obstructive pulmonary diseases, etc. Hence, we summarize the findings of bone-muscle crosstalk and propose potential strategies to ameliorate the skeletal or muscular symptoms of certain diseases. Overall, functional improvement of bones or muscles is beneficial to each other within the motor system. Furthermore, for diseases affecting organs such as the heart, kidney, lung, etc., enhancing muscle and bone health may contribute to preventing, attenuating symptoms and improving prognosis .
Keywords: Bone, Muscle, CKD, COPD, CAC
Received: 15 Apr 2025; Accepted: 24 Jul 2025.
Copyright: © 2025 Dong and Du. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Weijie Du, Harbin Medical University, Harbin, China
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