ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1612975
Prospective Analysis of Metabolic Syndrome and Inflammation in Aortic Aneurysm Risk: UK Biobank Study
Provisionally accepted
- Beijing Anzhen Hospital, Capital Medical University, Chaoyang District, China
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Context/Objectives: Metabolic syndrome (MetS) is associated with various diseases, yet its connection with aortic aneurysm (AA) is not well understood. The role of chronic inflammation as a mediator in this relationship also remains unclear. This study explores the combined effects of MetS and inflammation on AA risk.: Data from 312,505 UK Biobank participants were analyzed to assess the relationship between MetS and AA. Cox proportional hazards regression models evaluated the association, while restricted cubic splines, mediation analyses, interaction assessments, and joint analyses explored the impact of inflammatory indicators, including the low-grade chronic inflammation (INFLA) score. Results: Over a mean follow-up of 14.6 years, 2,382 participants developed AA. MetS was associated with a higher AA risk (HR: 1.27; 95% CI: 1.16-1.39) in fully adjusted models. Each additional MetS component increased AA risk by 16%. Inflammatory markers, including the INFLA score, significantly mediated this relationship. Joint analyses revealed a stronger association in MetS patients with high INFLA scores (HR: 1.68; 95% CI: 1.45-1.95).MetS and its components notably elevate AA risk, with inflammation playing a key mediating role. These findings underscore the importance of targeted prevention strategies, particularly for MetS populations with high chronic inflammation.
Keywords: metabolic syndrome, INFLA scores, chronic inflammation, Aortic Aneurysm, UK Biobank
Received: 16 Apr 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Liu, Liu, Chen, Gong, Ge, Qiao, Li and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Junming Zhu, Beijing Anzhen Hospital, Capital Medical University, Chaoyang District, China
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