CLINICAL TRIAL article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1614149
This article is part of the Research TopicExercise as a Central Pillar for Targeted Health and PerformanceView all articles
Effective of High-Intensity Interval Training and Moderate-Intensity Continuous Training on body composition, glycolipid metabolism and cardiopulmonary function in patients with pre-diabetes: A randomized controlled trial
Provisionally accepted
- The Second Affiliated Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, China
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Aims: To compare the effectiveness of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) on body composition, cardiovascular function, glycolipid metabolism and cardiopulmonary function in patients with pre-diabetes. Methods: 71 participants were randomly assigned to the HIIT (10 × 1-min at 75-90% HRpeak, intersperse with 1-min active recovery at 50% HRpeak) or MICT (50 min at 55-70% HRpeak) for an 12-week (3 times per week) program. The outcome measured was the change in body composition, cardivascular index, glycolipid metabolism and cardiopulmonary. The trial was registered on the Clinical Trial Registry (ChiCTR1900026905). Results: The body mass index (BMI) decreased in HIIT (P=0.016) and MICT group (P=0.021). The participants in MICT group had a significantly decreased in visceral adipose area (P=0.043) and body fat rate (P=0.030)after training, compared with HIIT group. Analysis of systolic blood pressure revealed statistically difference in the HIIT and MICT interventions (P<0.001) , but there was not statistical difference between groups (P=0.398). MICT was better than HIIT in reducing diastolic blood pressure (P=0.011). The significant effect of fasting blood glucose (FBG), 2h glucose and glycated hemoglobin (HbA1c) showed an obvious descend in the HIIT and MICT group (P<0.001). Regarding the blood lipid, triglyceride (TG) decreased significantly more in the MICT group than HIIT group (P=0.006). VO2peak increased in both HIIT and MICT groups, but there was no significant between-group difference (P=0.647). Conclusion: HIIT and MICT significantly improved blood glucose and aerobic capacity in patients with prediabetes.However, MICT was superior to that of HIIT in terms of visceral fat, lipids and diastolic blood pressure.
Keywords: prediabetes, High-intensity interval training, Body Composition, Glycolipid metabolism, Cardiopulmonary function
Received: 23 May 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 Chen, Wu, Zheng, Ni, Zhuang, Chen, Hu, Zou and Yin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lianhua Yin, The Second Affiliated Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, China
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