SYSTEMATIC REVIEW article
Front. Endocrinol.
Sec. Bone Research
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1617154
The effect of acupuncture-related therapies in animal model of postmenopausal osteoporosis: a meta-analysis and data mining approach
Provisionally accepted
- 1Clinical School of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
- 2Shenzhen Bao'an Traditional Chinese Medicine Hospital, Shenzhen, Guangdong Province, China
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Purpose:This meta-analysis and data mining aimed to investigate the effectiveness of Acupuncture-Related Therapies for animal models with Postmenopausal Osteoporosis (POMP) and to summarize the acupoints involved.Methods:This systematic review was conducted a comprehensive search of animal experiments using acupuncture-related therapies for the treatment of PMOP up to April 1, 2025. The primary outcome was bone mineral density (BMD). The secondary outcome indicators were estradiol(E2), blood calcium, osteocalcin(OC) and alkaline phosphatas(ALP).Meta-analysis was used to evaluate its efficacy, and data mining was used to explore the protocol for acupoint selection.Results: 27 Animal Experiments encompassing 548 animals with PMOP were analyzed. Metaanalysis displayed that compared with the conventional drug group, the acupuncture-related therapy group significantly increased the Estradiol(mean difference [MD] 2.37,95% confidence interval [95%CI] 1.15 to 3.58),Femoral BMD(mean difference [MD] 1.25,95% confidence interval [95%CI] 0.65 to 1.87),lumbar BMD(mean difference [MD] 1.88,95% confidence interval [95%CI] 1.27 to 2.49),Tibia BMD(mean difference [MD] 1.63,95% confidence interval [95%CI] 0.56 to 2.69).Data mining revealed that Zusanli (ST36), Shenshu (BL23), Guanyuan (CV4), and Sanyinjiao (SP6) were the core acupoints for PMOP treated by Acupuncture-Related Therapies.Conclusion:Acupuncture improved BMD and estrogen levels in animal models of PMOP. ST36, BL23, CV4, and SP6 are the core acupoints for acupuncture in PMOP,and this program is expected to become a supplementary treatment for PMOP.
Keywords: Acupuncture, Postmenopausal osteoporosis, Meta-analysis, Data Mining, acupoint 1.Introduction
Received: 03 May 2025; Accepted: 29 Sep 2025.
Copyright: © 2025 YU, Gao, Song, Chen and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Guangbin YU, 1768447067@qq.com
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