ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Thyroid Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1617229
Evaluation of Ultrasound Accuracy in Thyroid Mass Measurement and Its Impact on 131 I Treatment for Graves' Disease
Provisionally accepted
- Tianjin Medical University General Hospital, Tianjin, China
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Background: Thyroid mass is crucial for 131 I treatment of Graves' disease (GD). However, the accuracy of ultrasound (US) -based thyroid mass measurement remains controversial.Methods: This retrospective study included patients who underwent thyroid US and CT scans. The differences correlation, and agreement in thyroid mass measurements between the two methods were analyzed. Data from GD patients who received their first 131 I treatment were collected and evaluated at a 6-month follow-up. Regression analyses identified clinical factors for treatment efficacy and developed a predictive model.A statistically significant difference was observed in thyroid mass measurements exceeding 20 g between US and CT. (Z = -11.493, P<0.001). Despite a strong correlation between the two methods (r = 0.9809, P=0.001), the average relative error remained substantial (0.19±11.65%). Poor agreement was observed between CT and US (mean bias: 16.65g; ICC = 0.179, p = 0.087). Disease duration, FT4 level, 24 -hour radioactive iodine uptake, 131 I dose
Keywords: Graves' disease, Thyroid mass, 131 I treatment efficacy, Clinical predictive model, CT calibration
Received: 24 Apr 2025; Accepted: 10 Jul 2025.
Copyright: © 2025 Li, Han, Liu, Wang, Zheng, Ma, Zhang, Jia and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qiang Jia, Tianjin Medical University General Hospital, Tianjin, 300052, China
Wei Zheng, Tianjin Medical University General Hospital, Tianjin, 300052, China
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