REVIEW article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1618230
This article is part of the Research TopicThe Complex Phenotype of Diabetic Cardiomyopathy: Clinical Indicators and Novel Treatment Targets – Volume IIView all 6 articles
Study of independent diagnostic efficacy and co-diagnostic strategies of molecular markers for diabetic cardiomyopathy
Provisionally accepted
- The Second Affiliated Hospital of Shandong First Medical University, Tai’an, China
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Diabetic cardiomyopathy (DCM) is defined as myocardial dysfunction in diabetes mellitus (DM) patients independent of coronary artery disease (CAD) or hypertension (HTN). With high morbidity and mortality, DCM poses a significant threat to patient health. Its underlying pathogenesis remains incompletely elucidated, and the prolonged subclinical phase renders early diagnosis and precise treatment clinically challenging. Thus, identifying viable biomarkers for early diagnosis and intervention has emerged as a research imperative, whereas a systematic DCM diagnostic and therapeutic strategy remains to be established. Our examination revealed that circulating soluble suppression of tumorigenicity 2 (sST2), Cardiotrophin-1 (CT-1), and galectin-3 levels correlate closely with DCM progression stages. Combining Lysyl Oxidase-Like 2 (LOXL2) and Electron Transfer Flavoprotein β Subunit (ETFβ) measurements with ultrasound E/E' ratio and NT-proBNP enhances diagnostic accuracy. Novel noninvasive markers (e.g., skin autofluorescence) show promise. This article comprehensively evaluates the clinical applications of these molecular markers within DCM's pathophysiological classification framework.
Keywords: Diabetic cardiomyopathy, Molecular markers, Oxidative Stress, non coding RNA, early diagnosis
Received: 25 Apr 2025; Accepted: 23 Jul 2025.
Copyright: © 2025 su, zhao, guo and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mingfeng Cao, The Second Affiliated Hospital of Shandong First Medical University, Tai’an, China
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