ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1619370
This article is part of the Research TopicCommunity Series in Biology of C-reactive Protein: Volume IIView all 7 articles
Higher C-reactive protein to high-density lipoprotein cholesterol ratio is associated with hyperuricemia in diabetes and prediabetes: a crosssectional study
Provisionally accepted
- 1Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China
- 2Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng, Beijing Municipality, China
- 3Health Management Institute, the Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China
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The ratio of C-reactive protein to high-density lipoprotein cholesterol (CRP/HDL-c) reflects systemic inflammation and lipid status, both of which are implicated in uric acid metabolism. This study aimed to investigate the association between CRP/HDL-c and the prevalence of hyperuricemia (HUA) among adults with diabetes or prediabetes.Methods: This cross-sectional study included 10915 adults with diabetes or prediabetes from the Health Management Institute of the PLA General Hospital. Hyperuricemia was defined as a serum uric acid concentration ≥7 mg/dL in men and ≥6 mg/dL in women. Participants were divided into quartiles according to the ratio. Multivariate logistic regression and restricted cubic spline analyses were used to assess associations. Subgroup analyses and interaction tests were performed.Results: The prevalence of HUA increased across CRP/HDL-c quartiles (18.43%, 20.39%, 24.54%, and 29.82%; P < 0.001). Higher CRP/HDL-c levels were independently associated with increased HUA risk (odds ratio [OR] = 1.64, 95% confidence interval [CI]: 1.14-2.36; P = 0.008). Participants in the highest quartile had a significantly higher risk compared to those in the lowest quartile (OR = 1.33, 95% CI: 1.15-1.54; P < 0.001). The association was stronger in females (OR = 1.30) than in males (OR = 1.14), with a significant gender interaction (P for interaction = 0.031). Among females, the association was more pronounced in those aged <50 years (OR = 1.47). RCS analysis indicated a linear dose-response relationship.Conclusions: An elevated C-reactive protein to high-density lipoprotein cholesterol ratio is significantly associated with a higher risk of hyperuricemia in adults with diabetes or prediabetes, particularly in younger females.
Keywords: Hyperuricemia, CRP/HDL-c ratio, diabetes, prediabetes, Inflammation, Lipid Metabolism
Received: 28 Apr 2025; Accepted: 09 Jun 2025.
Copyright: © 2025 Guo, Huang, Ma, Zhao, Pan and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lixin Guo, Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China
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