ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Bone Research
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1621971
Sex differences in the Relationship Between Parathyroid Hormone and Uric Acid in Osteoporotic Fracture Patients: Insights from a Retrospective Cross-Sectional Study
Provisionally accepted
- 1First People's Hospital of Kunshan, Kunshan, China
- 2Kunshan municipal Health and Family Planning Information Center, Suzhou, Jiangsu, China
- 3Kunshan Center for Disease Control and Prevention, Suzhou, Jiangsu, China
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AbstractBackgroundOsteoporosis (OP) is characterized by decreased bone mineral density and increased fracture risk, particularly in older adults. The relationship between parathyroid hormone (PTH) and uric acid (UA) levels among osteoporotic fracture (OPF) patients remains unclear. This study aimed to investigate the association between PTH and UA in a large OPF patient cohort.MethodsIn this retrospective cross-sectional study, clinical data from 1,730 OPF patients admitted to Kunshan Hospital of Jiangsu University between January 2017 and August 2023 were analyzed. Baseline PTH and UA levels were measured, and analyses adjusted for age, sex, body mass index, and other clinical parameters. Multivariable logistic regression, smooth curve fitting, and threshold analyses were conducted.ResultsAfter stratifying by gender and adjusting for covariates, regression analysis revealed a significant positive association between PTH and UA in males, with each unit increase in PTH corresponding to a 2.19 µmol/L rise in UA (β=2.19, 95% CI: 1.27–3.12, p<0.01). Similarly, females exhibited a positive association, with each unit increase in PTH associated with a 0.88 µmol/L increase in UA (β=0.88, 95% CI: 0.35–1.40, p<0.01). Additionally, a nonlinear relationship was identified in female patients, with a UA inflection point at 26.14 µmol/L.ConclusionA significant positive correlation between PTH and UA levels exists among OPF patients, with males exhibiting a linear and females a nonlinear relationship. These findings highlight the importance of gender-specific personalized management strategies in clinical practice.
Keywords: osteoporotic fracture, Parathyroid Hormone, Uric Acid, sex differences, BMD
Received: 07 May 2025; Accepted: 29 Sep 2025.
Copyright: © 2025 Zhu, Zhou, Lu, Li, Wei, Jin, Hu and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yi-jun Gao, gaoyijun2010@163.com
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