ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1623136
This article is part of the Research TopicHot Topics in Diabetes and Steatotic Liver DiseaseView all 14 articles
Impact of a high dietary fiber cereal meal intervention on the progression of liver fibrosis in T2DM with MASLD
Provisionally accepted
Xi-Shuang ChenHui-Zhen LiuYue-Xia Han*Sui-Jun Wang*Fang Huang
Jingxian FangJian MengQing GuXue HuQian-Wen MaHui-Ming ZouYu Han- Shanghai Shidong Hospital of Yangpu District, Shanghai, China
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Aims: This study aimed to investigate the ameliorative effect of dietary fiber on hepatic fibrosis in T2DM combined with MASLD and to seek the appropriate dose of DF for this population. Material & methods: This study was a randomized, controlled, open clinical trial. Patients with T2DM and MASLD were recruited from January 2024 to March 2024 in our hospital using the Interactive Web Response System (IWRS) in a 1:1:1 ratio randomly divided into 3 groups. The control patients received traditional diabetes education. Based on health education, the intervention group took DF supplements (Shanghai Jiuben Technology Co., Ltd.) daily for 12 weeks. Each packet of the supplement is 50 grams and contains approximately 12 grams of dietary fiber (DF). The intervention group was randomly assigned to two different groups. One group received 24 grams of fiber, which was obtained by consuming two packets, each containing 12 grams of fiber. The other group received 12 grams of fiber by consuming one packet. Results: Both interventions showed a more significant decrease in HbA1c levels than the control group, but only the difference between the control and 24g intervention groups was statistically significant(-0.6 ± 0.5 vs -1.6 ± 0.6, P<.001). The 24g intervention group showed a substantial decrease in FPG compared to the control group and the 12g intervention both at week 8 and week 12 (p < 0.05). Both 3 intervention groups experienced significant reductions in FIB-4 levels (p<0.05), with the intervention with 24g group showing the most significant decrease. Conclusion: Our study demonstrated that dietary fiber improved liver fibrosis and glycemic control, with a more pronounced effect in patients from the 24g Intervention group. However, this group had no statistically significant change in BMI, possibly due to higher caloric intake from additional fiber.
Keywords: diabetes, Nutritional intervention, liver fibrosis, Transient elastography, Fibrosis-4 index (FIB-4)
Received: 05 May 2025; Accepted: 13 Aug 2025.
Copyright: © 2025 Chen, Liu, Han, Wang, Huang, Fang, Meng, Gu, Hu, Ma, Zou and Han. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yue-Xia Han, Shanghai Shidong Hospital of Yangpu District, Shanghai, China
Sui-Jun Wang, Shanghai Shidong Hospital of Yangpu District, Shanghai, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.