ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Thyroid Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1623881
This article is part of the Research TopicThe Association of Other Autoimmune Diseases in Patients with Thyroid Autoimmunity: Volume IIView all 25 articles
Expression Levels of T Cell-Related Immune Factors and Their Correlation with Thyroid Function in Graves' disease with Varied Serum Iodine Status: Insights into Immunopathogenesis
Provisionally accepted
- Second Affiliated Hospital of Harbin Medical University, Harbin, China
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Objective: Measurement of Serum Iodine Concentration (SIC) in Newly Diagnosed Adult Graves' Disease (GD) Patients with Hyperthyroidism and Healthy Controls: Investigating Cytokine Expression Profiles and Their Correlations with Thyroid Function Across Diverse Iodine Nutritional Status. Method: Patients newly diagnosed with GD hyperthyroidism from September 2024 to February 2025 at our institution were enrolled. Serum samples were collected for SIC measurement using arsenic-cerium catalytic spectrophotometry. Serum cytokine levels of 12 Th cell-related cytokines were quantified via LEGENDplex™ Human Th Cytokine Panel, and thyroid function was assessed by electrochemical immunoassay. Participants were stratified into three groups based on WHO iodine status criteria: iodine deficiency (<45 μg/L), adequate iodine (45-90 μg/L), and iodine excess (>90 μg/L). Pearson/Spearman correlation analyses were performed to evaluate associations between cytokine profiles and thyroid function parameters across subgroups.Results: Based on the inclusion and exclusion criteria, a total of 75 subjects were enrolled in this study. The SIC was 148.62 ± 17.63 μg/L (GD I group), 72.33 ± 12.08 μg/L (GD II group), and 75.24 ± 7.94 μg/L (NC group), respectively, with statistically significant differences among the three groups (P<0.001). In GD patients, SIC showed a positive correlation with TRAb levels (r = 0.136, P<0.001).
Keywords: Iodine excess, T cell subsets, Cytokines, Thyroid function, Graves' disease hyperthyroidism
Received: 06 May 2025; Accepted: 28 Jul 2025.
Copyright: © 2025 wang, Shengnan, Lv, Kerou and Hong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: lilan wang, Second Affiliated Hospital of Harbin Medical University, Harbin, China
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