ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cancer Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1625989
This article is part of the Research TopicEndocrine Dysfunctions and Immunometabolic Pathways in Autoimmune-Related CancersView all 6 articles
Clinicopathological Features and Outcomes in Patients with Concurrent Medullary and Papillary Thyroid Carcinoma
Provisionally accepted
- 1West China Hospital, Sichuan University, Chengdu, China
- 2west China Hospital, Sichuan University, chengdu, China
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Abstract Objective: The co-existence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) is rare. The study analyzed the clinicopathological findings and prognosis of concomitant PTC in MTC patients. Methods: Clinicopathological data and follow-up outcomes of 25 patients with concurrent medullary and papillary thyroid carcinoma (combination group) between January 2009 and May 2024 were collected and analyzed retrospectively. We compared clinicopathologic characteristics and follow-up outcomes between patients with concurrent MTC and PTC (combination group) and those with MTC alone (MTC group). Results: The 25 patients with concurrent MTC and PTC comprised 19 females and 6 males. There were no statistically significant differences between the combination group and the MTC group in terms of age, gender, or pathological features such as the diameter of MTC lesions, mulifocality, extra-thyroidal extension (ETE), number of lymph node (LN) resected, the number of LN metastasis, the maximum diameter of LN metastasis, and TNM staging. The recurrence rate was similar between the two groups. Univariate analysis showed that the max tumor diameter, capsule invasion, extracapsular invasion and recurrent nerve invasion were associated with the risk of biochemical/structural abnormalities in MTC group. Multivariate analysis showed that only the max tumor diameter and capsule invasion were significant independent prognostic factors for biochemical/ structural abnormalities. Conclusion: The result of this comparative study between patients with MTC and PTC co-existence and those with MTC alone showed similar invasiveness and prognosis.
Keywords: medullary thyroid carcinoma, Papillary thyroid carcinoma, concurrent, prognosis, thyroid cancer
Received: 09 May 2025; Accepted: 18 Jul 2025.
Copyright: © 2025 Wang, Sun, Liu, Liu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yichao Wang, West China Hospital, Sichuan University, Chengdu, China
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