ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1627560
Anti-Müllerian Hormone and Inhibin B Dynamics in Polycystic Ovary Syndrome: Correlation with Controlled Ovarian Hyperstimulation Outcomes and Pregnancy Success
Provisionally accepted
Yueying Li1,2*
Lu Han1,2Ying He1,2Xiaoyan Li1,2Yan Zhang1,2
Huiying Zhang1,2
Yingmei Wang1,2Huijuan Zhang1,2
Tian Wenyan1,2- 1Tianjin Medical University, Tianjin, China
- 2Tianjin Medical University General Hospital, Tianjin, China
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Purpose: To investigate the dynamic changes of serum Anti-Müllerian Hormone (AMH) and Inhibin B (INHB) during controlled ovarian hyperstimulation (COH) in patients with polycystic ovarian syndrome (PCOS) and analyze their correlation with COH outcomes and pregnancy success. Methods: A total of 40 individuals diagnosed with PCOS and 40 control subjects were recruited for the study. Serum concentrations of AMH and INHB were quantified at several key time points: at the initiation of gonadotropin treatment (dGn), on the fifth day of stimulation (dGn5), on the day of hCG administration (dhCG), on the day of oocyte pick-up (dOPU), and within the follicular fluid (FF) collected on the day of oocyte retrieval, employing the ELISA method for analysis. The changes in their concentrations were explored, and their correlations with COH outcomes and pregnancy success were analyzed. Results: AMH peaks on the basal day and subsequently declines during the COH procedure. The serum AMH levels are consistently correlated with estradiol (E2) on the trigger day, retrieved oocytes, two pronuclei (2PN) fertilization, available embryos, and top-quality embryos (TQE) rate(p<0.05). INHB elevates during the COH process, peaks at dHCG, and thereafter declines. Serum levels are closely associated with E2 on the trigger day, retrieved oocytes, 2PN fertilizations, available embryosand and TQE rate(p<0.05). During COH, AMH and INHB in both FF and serum are interrelated. AMH levels on dOPU (β=-4.3610, P<0.01) and INHB levels on dOPU (β=-0.1094, P<0.05) were significant negative predictors of the TQE rate. Serum INHB at dGn5 demonstrated predictive value for pregnancy outcomes (AUC=0.74, 95% confidence interval: 0.62–0.87). Conclusion: During COH, serum AMH and INHB exhibit cyclical variations.Serum AMH and INHB especially on dOPU are closely associated with the outcomes of COH. They possess the capacity to predict the results of COH. Moreover, serum INHB (dGn5) may serve as a potential biomarker for individualized prediction of pregnancy success in PCOS patients.
Keywords: pcos, CoH, AMH, INHB, Pregnancy
Received: 13 May 2025; Accepted: 27 Aug 2025.
Copyright: © 2025 Li, Han, He, Li, Zhang, Zhang, Wang, Zhang and Wenyan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yueying Li, Tianjin Medical University, Tianjin, China
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