REVIEW article
Front. Endocrinol.
Sec. Gut Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1628094
This article is part of the Research TopicBidirectional Gut-Brain Interactions in Modulating Central Nervous System DiseasesView all 4 articles
Tar geting the Br ain-Gut-Pr ostate Axis in Chr onic Pr ostatitis: Mechanisms and Ther apeutics
Provisionally accepted
- 1People's Liberation Army Joint Logistics Support Force 940th Hospital, Lanzhou, China
- 2中国人民解放军联合后勤保障部队第 940 医院, 兰州市, China
- 3940, lanzhou, China
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Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), a refractory urinary system disorder, is closely associated with dysregulation of the brain-gut-prostate axis. Emerging evidence highlights the pivotal role of gut microbiota dysbiosis and its bidirectional interactions with the neuroimmune system in CP/CPPS pathogenesis. This systematic review integrates perspectives from microbiomics, neuroimmunology, and metabolomics to propose a theoretical framework of the brain-gut-prostate axis and multi-dimensional therapeutic strategies targeting this axis. By transcending conventional localized anti-inflammatory approaches, these strategies aim to address clinical resistance and phenotypic heterogeneity. Mechanistic insights into microbiota-derived metabolites (e.g., short-chain fatty acids, SCFAs), neuroendocrine signaling (e.g., thyrotropin-releasing hormone, TRH), and immune crosstalk (e.g., Th17/Treg imbalance) are explored, alongside innovative therapies such as microbiome modulation, neural interventions, and immune regulation. This holistic paradigm not only provides new mechanistic insights but also offers promising avenues for personalized management and translational research in CP/CPPS, potentially overcoming current therapeutic bottlenecks.
Keywords: Chronic Prostatitis, Gut Microbiota, neuroimmune interactions, Therapeutics Dehui Chang, Master's degree, Chief Physician, CP/CPPS
Received: 15 May 2025; Accepted: 09 Jun 2025.
Copyright: © 2025 Song, chang, zhang, zhang, yin and yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: dehui chang, People's Liberation Army Joint Logistics Support Force 940th Hospital, Lanzhou, China
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