ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1629741
The Impact of a Complete Nutrition Diabetic Formula on Glycemic Control and Nutritional Status in Hospitalized Patients with Diabetes Mellitus
Provisionally accepted
- 1Department of Nutrition, Chung Shan Medical University, Taichung, Taiwan
- 2Le Bonta Wellness Co. Ltd., Shanghai, China
- 3Research and Development Center, Standard Investment (China) Ltd., Shanghai, China
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The clinical application of specialized oral nutritional supplements (ONS) in managing hospitalized patients with diabetes mellitus necessitates rigorous evaluation of their effects on glycemic stability and nutritional parameters. This prospective study aimed to investigate the impact of a diabetes-specific ONS, Complete Nutrition Diabetic Formula, on glycemic control and key nutritional indices in diabetic inpatients. Forty adult inpatients diagnosed with diabetes mellitus requiring nutritional support were enrolled and completed the intervention. Following assessment of individual caloric requirements, participants received an average daily supplementation of 156 g (equivalent to 2.6 packs) of the Complete Nutrition Diabetic Formula over a mean duration of 29 days (range 14-67 days). Glycemic parameters, anthropometric measurements (including mid-arm circumference, MAC), and pertinent biochemical markers (including serum magnesium) were assessed at baseline and study conclusion. Post-intervention analysis showed a higher total caloric and fat intake with a lower carbohydrate share, accompanied by significant gains in mid-arm circumference (MAC), serum magnesium, and a nitrogen-balance flip from -2.7 g/day to +1.25 g/day (p < 0.05), marking a catabolic -to -anabolic shift and confirming protein repletion. Fasting plasma glucose and other biochemical indices -including serum proteins and lipid profiles -remained unchanged (p > 0.05), indicating that short-term Complete Nutrition Diabetic Formula supplementation improves key nutritional indicators without compromising glycemic control or broader metabolic stability.
Keywords: diabetes, Oral nutritional supplements (ONS), glycemic control, Nutritional Status, Mid-Arm Circumference (MAC)
Received: 16 May 2025; Accepted: 16 Jun 2025.
Copyright: © 2025 Wang, Li, Sun and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shengqian Sun, Research and Development Center, Standard Investment (China) Ltd., Shanghai, China
Tristan C Liu, Le Bonta Wellness Co. Ltd., Shanghai, China
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