ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Pituitary Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1630037
Cardiac Structure and Function Recovery in Acromegaly After Treatment: Insights from Cardiac Magnetic Resonance Imaging
Provisionally accepted
Yu Chen
Yangjie LiYu Tang
Jing Li
Yerong Yu
Huiwen TanBowen CaiShu Jiang
Wei WangSongping Zheng
Peizhi ZhouYi WeiJiayu Sun
Yucheng Chen*Jianwei Li*- West China Hospital, Sichuan University, Chengdu, China
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Purpose: Cardiac magnetic resonance imaging (CMRI) provides a detailed method for understanding the specific cardiovascular alterations associated with acromegaly. This study aimed to evaluate the impact of personalized treatment on cardiac structure, function, and myocardial tissue characteristics using CMRI, and to assess the effects of biochemical remission on improving cardiovascular complications in acromegaly patients .Method: Thirty-nine acromegaly patients were enrolled from July 2020 to February 2023 at West China Hospital of Sichuan University. Comprehensive cardiac assessments were conducted using a 3.0 T MRI scanner at baseline and one year after individualized treatment.Results: Among the 30 patients who completed both baseline and one-year follow-up CMRI examinations, significant reductions in left ventricular (LV) wall thickness and end-diastolic diameter were observed compared to baseline (both P < 0.05). Left ventricular mass (LVM) and mass index (LVMi) also significantly decreased (LVM: 90.17±25.86 g vs. 101.18±26.10 g, P=0.007; LVMi: 50.01±12.56 g/m 2 vs. 56.20±13.01 g/m² , P=0.008). Additionally, T2 values showed a significant reduction following individualized treatment (basal T2: 39.12±2.82 ms vs. 42.91±4.38 ms, P<0.001; apical T2: 41.96±3.87 ms vs. 45.13±4.87 ms, P=0.021). Compared to healthy controls, patients who achieved biochemical remission exhibited increased LV inferior septal thickness and elevated elevated extracellular volume (ECV) values. However, T2 value in the basal layer of the LV was significantly lower in the remission group compared to healthy controls.Patients with acromegaly exhibited LV hypertrophy, enlargement, myocardial fibrosis and impaired systolic function assessed by CMRI compared with healthy controls. Individualized treatment led to partial reversed of these abnormalities, particularly in those who achieved biochemical remission.
Keywords: Acromegaly, cardiac magnetic resonance imaging, Heart structure, cardiac function, Myocardial lesions
Received: 16 May 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 Chen, Li, Tang, Li, Yu, Tan, Cai, Jiang, Wang, Zheng, Zhou, Wei, Sun, Chen and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yucheng Chen, West China Hospital, Sichuan University, Chengdu, China
Jianwei Li, West China Hospital, Sichuan University, Chengdu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.