REVIEW article
Front. Endocrinol.
Sec. Pituitary Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1634206
This article is part of the Research TopicAdvances in Understanding and Managing Skull Base PathologiesView all articles
Sphenoid Sinus Hyperpneumatization: Anatomical Variants, Molecular Blueprints, and AI-Augmented Roadmaps for Skull Base Surgery
Provisionally accepted
Andra Ioana BaloiuFlorin Filipoiu*Corneliu Toader*
Razvan-Adrian Covache-BusuiocOctavian Munteanu
Matei Serban*- Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
This manuscript discusses sphenoid sinus hyperpneumatization as an anatomical variation that may hold clinical relevance in t he context of transsphenoidal surgery, particularly for pituitary and parasellar lesions. While often overlooked, these variants can alter surgical access, increase the risk of neurovascular injury, and potentially affect outcomes in endocrine tumor resections.We have aimed to provide a multidisciplinary synthesis, incorporating anatomical development, relevant molecular pathways, and advanced imaging techniques. In doing so, we hope to support a more nuanced understanding of how sphenoid sinus anatomy may influence surgical planning and endocrine care.Given the close relationship between the sphenoid sinus, the sellar region, and the hypothalamic-pituitary axis, we believe this topic may be of interest to readers focused on pituitary disorders, neuroendocrine surgery, and skull base imaging. We respectfully submit this work in the hope that it might offer a modest contribution to the field.
Keywords: Hyperpneumatization, Skull base anatomy, Transsphenoidal surgery, Cerebrospinal fluid leakage, Neurovascular injury, advanced imaging, artificial intelligence
Received: 23 May 2025; Accepted: 04 Aug 2025.
Copyright: © 2025 Baloiu, Filipoiu, Toader, Covache-Busuioc, Munteanu and Serban. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Florin Filipoiu, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Corneliu Toader, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Matei Serban, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.