REVIEW article
Front. Endocrinol.
Sec. Systems Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1634814
This article is part of the Research TopicMetabolic Regulation and Signal Transduction by the purine/purinergic system: Are we there yet?View all articles
Inosine: biofunctions and the roles in human diseases
Provisionally accepted
- School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Inosine, a basic component of purine nucleotide, was mainly seen as only the building block in nucleotide synthesis. It is also a versatile bioactive molecule with diverse biofunctions. These biofunctions are strongly related to human diseases or pathological conditions, such as cancer, obesity, inflammation, neurodegenerative diseases autoimmune diseases, etc. In this article, we will discuss the roles and functions of inosine in a wide array of human diseases, targeting metabolism modulation, purinergic signaling and RNA editing. We will also mention its great importance as a biomarker of human diseases. We believe that a more thorough understanding of inosine and its intricate roles in various human diseases could inspire future therapeutic methods or preventive modalities for these diseases.
Keywords: Inosine, Metabolism, purinergic signaling, RNA Editing, human diseases
Received: 25 May 2025; Accepted: 22 Sep 2025.
Copyright: © 2025 LI, Zhang, Kang, Tong, Zhang and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ping Zhang, ssmuzp@sjtu.edu.cn
Yemin Zhu, kringsley2004@aliyun.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.