CASE REPORT article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1635004
This article is part of the Research TopicInnovative Therapeutic Strategies for Managing Diabetic Foot Ulcers and Mitigating Associated ComplicationsView all 7 articles
Sequential treatment for diabetic foot ulcers in aortic dissection patients: A case report
Provisionally accepted
- 1Beijing Longfu Hospital, Beijing, China
- 2China Academy of Chinese Medical Sciences, Beijing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Diabetic foot ulcers (DFUs) represent a prevalent complication of diabetes, with a lifetime risk ranging from 15% to 25% among diabetic patients. Research indicates that anticoagulation plays a crucial role in the management of newly diagnosed cases of diabetic lower extremity atherosclerotic obliterative disease [1] . However, in the present case, the patient developed dry gangrene in both toes after receiving vasodilator drugs during an emergency intervention for sudden aortic dissection.Given that traditional treatments, such as anticoagulation and transfemoral amputation, may not be appropriate for every case, it is imperative to explore alternative therapeutic options. This case report presents pioneering clinical evidence of a tri-therapeutic strategy integrating biomechanical conditioning transverse tibial bone transport (TTBT), Traditional Chinese Medicine Compress Therapy (TCM-CT), and antibiotic-loaded bone cement (ALBC) for diabetic foot ulcer regeneration. This innovative paradigm demonstrates concurrent activation of mechanobiological signaling pathways, phytochemical bioactivity, and sustained antimicrobial protection, achieving complete epithelialization in refractory neuropathic wounds.
Keywords: diabetic foot ulcer (DFU), antibiotic-loaded bone cement (ALBC), Aortic dissection (AD), case report, transverse tibial bone transport
Received: 25 May 2025; Accepted: 16 Jul 2025.
Copyright: © 2025 Liang, Deng and Ding. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Huan Liang, Beijing Longfu Hospital, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.