ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1636484
Association between Obstructive Sleep Apnea and Male Reproductive Function: A Cross-sectional Study with Stratified Analysis
Provisionally accepted
- 1Second Hospital of Anhui Medical University, Hefei, China
- 2The First Affiliated Hospital of Anhui Medical University, Hefei, China
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Abstract Objective: Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common sleep disorder known to affect systemic physiology. Emerging evidence suggests a potential relationship between OSA and male reproductive health, but this association remains insufficiently characterized. This study aims to explore the link between OSA, semen quality, and sex hormone profiles in reproductive-aged men. Method: A total of 108 newly diagnosed OSA patients aged 20–40 years, who underwent full-night polysomnography (PSG) at the Respiratory Sleep Center of the Second Affiliated Hospital of Anhui Medical University between 2022 and 2024, were included. The control group consisted of 84 healthy adult males undergoing fertility evaluations during the same period at the same hospital. All participants completed physical examinations, semen analysis, and sex hormone testing. OSA severity was classified based on the apnea–hypopnea index (AHI) obtained from PSG in the patient group. Results: Compared with controls, men with OSA had significantly higher body weight and BMI, as well as lower sperm concentration (90.0 vs. 129.3 ×10⁶/ml), total motility (68.6% vs. 71.0%), progressive motility (63.8% vs. 66.6%), and testosterone levels (13.1 vs. 21.8 nmol/L) (all p < 0.01). Stratified analyses showed a stepwise decline in semen parameters and oxygen saturation with increasing OSA severity. In multivariable analysis, AHI was independently associated with reduced sperm concentration (β = –0.393), total motility (β = –0.640), and progressive motility (β = –0.623) (all p < 0.001). Conclusion: OSA is independently associated with impaired semen quality and lower testosterone levels in reproductive-aged men. These findings 3 highlight the potential reproductive consequences of untreated OSA and underscore the importance of early screening and intervention.
Keywords: obstructive sleep apnea, Reproductive Health, Semen parameters, sex hormones, Testosterone
Received: 28 May 2025; Accepted: 02 Sep 2025.
Copyright: © 2025 Zhang, Wu, Zhang, Gao, Liu, Geng, Zou and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wei Zhang, Second Hospital of Anhui Medical University, Hefei, China
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