ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1637373
This article is part of the Research TopicAddressing insulin resistance and hyperinsulinemia for cardiovascular disease preventionView all 14 articles
Correlation between loge GDR and hyperuricemia in patients with type 2 diabetes mellitus: a cross-sectional study
Provisionally accepted
- 1Linyi People's Hospital, Linyi, China
- 2Shandong Second Medical University, Weifang, China
- 3Affiliated Hospital of Jining Medical University, Jining, China
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Introduction: Hyperuricemia (HUA), an important health concern, is closely associated with insulin sensitivity. The natural log transformation of the glucose disposal rate (loge GDR) is a new model of insulin sensitivity in patients with type 2 diabetes mellitus (T2DM). The association between HUA and insulin resistance has been demonstrated by other insulin resistance indices. However, the correlation between loge GDR and HUA has not been explored. This study explored the interaction between loge GDR and HUA in patients with T2DM. Methods: This study involved 2352 patients with T2DM. Biochemical and clinical data were collected. Morning blood samples were collected after an overnight fast for serum uric acid measurement. All the parameters required for loge GDR calculation, including triglycerides, γ-glutamyl transferase, urinary albumin-to-creatinine ratio, and body mass index, were also collected. The correlation between the loge GDR and HUA was analyzed. Results: Patients with HUA had lower loge GDR values than those without (P < 0.001). HUA prevalence decreased significantly with increasing loge GDR quartiles (P < 0.001). Multivariable regression analysis revealed that loge GDR was independently associated with HUA (odds ratio: 0.279, 95% confidence interval: 0.170–0.459). Loge GDR's area under the receiver operating characteristic curve (0.706, 95%CI = 0.664-0.747) was superior to other indices. Discussion: Loge GDR correlates strongly with HUA and demonstrates significant HUA predictive value in patients with T2DM.
Keywords: type 2 diabetes mellitus, Hyperuricemia, insulin sensitivity, loge GDR, Insulinresistance
Received: 29 May 2025; Accepted: 10 Sep 2025.
Copyright: © 2025 Peng, Liu and Ji. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yan Peng, 13665399146@163.com
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