ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Bone Research
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1637624
The effect of type 2 diabetes on periapical osteoclast related factors during axial tooth movement
Provisionally accepted
- 1Second Hospital of Tianjin Medical University, Tianjin, China
- 2Department of Stomatology, Shanxi Medical University, Taiyuan, Shanxi Province, China
- 3The Second Clinical Medical Department of Shanxi Medical University, Taiyuan, Shanxi Province, China
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To explore the impact of type 2 diabetes on tooth axial elongation and its relationship with osteoclast-related factors, we established the unopposed molars mice model. Micro-CT analysis showed that tooth elongation and bone mineral density (BMD) in both groups increased over time but were consistently lower in diabetic mice compared to controls. Histological staining showed that diabetic mice had more osteoclasts and bone resorption, with sparser collagen. Immunohistochemistry and RT-qPCR showed that the expression levels of osteopontin (OPN), receptor activator for nuclear factor-κ (RANK) and Receptor Activator of Nuclear Factor-κ B Ligand (RANKL) in both groups increased over time but were higher in diabetic mice compared to controls. In conclusion, type 2 diabetes may slow down the axial elongation of teeth. The aggravate bone resorption based on abnormal expression of RANK, RANKL and OPN was probable reason of inhibition of alveolar bone remodeling.
Keywords: type 2 diabetes, osteoclast, axial tooth movement, Rank, RANKL, OPN
Received: 29 May 2025; Accepted: 06 Aug 2025.
Copyright: © 2025 Shi, Lin, Shi, Zhao, An, Xu, Zhu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wenjin Li, The Second Clinical Medical Department of Shanxi Medical University, Taiyuan, Shanxi Province, China
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