REVIEW article
Front. Endocrinol.
Sec. Experimental Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1645540
This article is part of the Research TopicEndocrine Disruptors Affecting Human and Companion Animal Endocrine Function: Similarities and Indicators in the One Health Concept – Volume IIView all articles
PRENATAL EXPOSURE TO BISPHENOL-A AS A RISK FACTOR FOR INFANT NEURODEVELOPMENT
Provisionally accepted
Ivan Hazel Bello-Cortes1
Jose Antonio Garcia Garcia2
Manuel Gutierrez-Aguilar1Daniela Araiza-Olivera3Celia Sanchez-Perez1Gabriela García-Cerón1
Sofia Moran-Ramos1
Hugo Tovar4Andrea Bonilla-Brunner5
Roeb Garcia-Arrazola1*- 1Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
- 2Hospital General de Mexico Dr Eduardo Liceaga, Mexico City, Mexico
- 3Fox Chase Cancer Center, Philadelphia, United States
- 4Instituto Nacional de Medicina Genomica, Mexico City, Mexico
- 5Bioplaster Research Inc., Delaware, United States
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It has been established a chronic human exposure to a particular class of chemicals known as endocrine-disrupting compounds (EDCs). Studies conducted in vitro, in vivo, and in silico have demonstrated that EDCs can disrupt the endocrine system through epigenetic mechanisms. These changes can be heritable and are associated with a wide range of diseases.Since exposure concentrations of these compounds are measured in parts per million (ppm) or even parts per billion (ppb), a critical question arises: does this pose a significant risk to humankind and future generations?We conducted a comprehensive review of human epidemiological data to provide an assessment of the risk of neurodevelopmental disorders in children associated with maternal exposure to Bisphenol A (BPA). BPA is one of the most studied and relevant EDC's related to food exposure. Our analysis reveals a correlation between BPA exposure during pregnancy and behavioral issues in offspring on 80% of the reviewed articles. Notably, male infants exposed to BPA during the third trimester exhibited a heightened risk. Our findings highlight the importance of considering potential new health regulations aimed at safeguarding the fetal environment and reducing the risk of neurodevelopmental disorders in children.
Keywords: bisphenol A, Prenatal exposure, neurodevelopment, behavioural assessment, Systematic review
Received: 11 Jun 2025; Accepted: 07 Aug 2025.
Copyright: © 2025 Bello-Cortes, Garcia Garcia, Gutierrez-Aguilar, Araiza-Olivera, Sanchez-Perez, García-Cerón, Moran-Ramos, Tovar, Bonilla-Brunner and Garcia-Arrazola. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Roeb Garcia-Arrazola, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
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