CASE REPORT article
Front. Endocrinol.
Sec. Bone Research
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1645715
Case Report: management of multiple brown tumors after kidney transplantation
Provisionally accepted
- Hainan General Hospital, Haikou, China
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Brown tumor is usually caused by primary or secondary hyperparathyroidism but are exceptionally rare after kidney transplantation. Their rarity and atypical pathological features make diagnosis and treatment particularly challenging. We present a case of a 38-year-old woman with multiple brown tumors secondary to persistent hyperparathyroidism following kidney transplantation.The patient was initially admitted to the orthopedic department for left shoulder dislocation and lytic lesions in the left humerus and was diagnosed with a giant cell tumor of bone. Further investigations revealed elevated parathyroid hormone levels and multiple lytic bone lesions throughout the skeleton. Based on these findings, the patient was ultimately diagnosed with multiple brown tumors. As a result, the patient underwent total parathyroidectomy and autotransplantation of parathyroid tissue. Follow-up evaluations showed decreased parathyroid hormone levels and alkaline phosphatase levels, with improvement in skeletal changes. This case report shares the experience and lessons in managing hyperparathyroidism, both before and after kidney transplantation, emphasizing the importance of clinicians’ awareness of the disease and multidisciplinary collaborative management.
Keywords: Brown tumor, Kidney Transplantation, Secondary hyperparathyroidism, Parathyroid Hormone, case report
Received: 12 Jun 2025; Accepted: 01 Sep 2025.
Copyright: © 2025 Sun, Bai, Chen and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hong Li, Hainan General Hospital, Haikou, China
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