ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Translational and Clinical Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1646307
This article is part of the Research TopicAcute Pancreatitis Infection: Epidemiology, Prevention, Clinical Characteristics, Treatment, and Prediction: Volume IIView all 5 articles
The Impact of Hyperinsulinemia on Short-term Prognosis in Patients with Hypertriglyceridemia-induced Acute Pancreatitis
Provisionally accepted
- 1The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China
- 2Wuhu Hospital of Traditional Chinese Medicine, Wuhu, China
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The short-term prognosis of hyperinsulinemia in patients with hyperlipidemia resulting in acute pancreatitis remains uncertain, so this research explores the correlation between them.: This study retrospectively analyzed patients treated for hypertriglyceridemic acute pancreatitis at Wuhu Hospital of Traditional Chinese Medicine between January 2020 and April 2023. Patients were divided into two groups based on laboratory diagnosis: the hyperinsulinemia group (HINS) and the non-hyperinsulinemia group (NHINS).The study aims to evaluate the short-term effects of hyperinsulinemia on acute pancreatitis.Results: A total of 92 patients with Hypertriglyceridemic pancreatitis were included in the study before receiving lipid-lowering therapy, with 59 in the HINS group and 33 in the NHINS group. Significant differences were observed between the two groups in terms of white blood cell count (WBC), hypersensitive C-reactive protein (CRP) levels, and fasting blood glucose at 2, 3-4, and 5-7 days after initiation of lipid-lowering intervention (P < 0.05).Following admission, patients received symptomatic interventions. However, there was a significant difference in the rate of decrease compared to the baseline between the fifth and seventh days (P < 0.05). Additionally, the groups showed significant differences in the readmission rates for recurrent pancreatitis within 30 days post-ICU transfer and discharge (P < 0.05). No statistically significant distinctions were noted in the length of hospital stay or quality of life scores fifteen days post-discharge.Hyperinsulinemia adversely affects the recovery process of patients with Hypertriglyceridemia-induced acute pancreatitis.
Keywords: acute pancreatitis, Hypertriglyceridemia, hyperinsulinemia, Short-term prognosis, endocrine
Received: 13 Jun 2025; Accepted: 01 Sep 2025.
Copyright: © 2025 Wang, Zheng, Qian and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Long Qian, Wuhu Hospital of Traditional Chinese Medicine, Wuhu, China
Maoqi Xu, Wuhu Hospital of Traditional Chinese Medicine, Wuhu, China
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