ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1648823
This article is part of the Research TopicAddressing insulin resistance and hyperinsulinemia for cardiovascular disease preventionView all 13 articles
The Relationship between Novel Inflammatory Markers SII, SIRI, MHR, UHR and Insulin Resistance in Patients with Type 2 Diabetes: Based on a Retrospective Analysis
Provisionally accepted
- 1Xi'an International Medical Center Hospital, Xi'an, China
- 2Xi'an Daxing Hospital, Xi'an, China
- 3Chang 'an District Center for Disease Control and Prevention, Xian, China
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Objective: This study aims to investigate the relationship between newly identified inflammatory indicators and IR in patients with T2DM, thereby providing a reference basis for the early clinical prevention, diagnosis, and treatment of IR in patients with T2DM. Methods: A total of 779 patients with T2DM admitted to the Endocrinology Department of our hospital from January 2022 to December 2024 were included in the observation group. Five hundred healthy individuals who underwent physical examinations during the same period were randomly selected as the control group. Patients in the observation group were divided into the IS group, the EIR group, and the SIR according to the HOMA-IR level. Analyze the relationship between the four indicators and IR in patients with T2DM, and observe whether they are independent risk factors for IR in T2DM patients, as well as analyze their clinical utility. Results: Compared with the control group, the levels of inflammatory indicators SII, SIRI, MHR and UHR in the observation group were significantly increased. The levels of SII, SIRI, MHR and UHR in the EIR group and the SIR Group were significantly higher than those in the IS group. Moreover, with the increase in HOMA-IR score, all four inflammatory indicators showed an upward trend. The results of Spearman's rank correlation analysis showed that all four indicators were positively correlated with IR in patients with T2DM. Multivariate ordered logistic regression analysis showed that all four indicators were independent risk factors for IR in patients with T2DM. The ROC results indicated that SII, SIRI, MHR and UHR could serve as potential discriminatory ability indicators for evaluating the degree of IR in patients with T2DM. Conclusion: The levels of SIRI, SII, UHR and MHR in patients with T2DM increase and are positively correlated with IR. They are independent risk factors for IR in patients with T2DM and have clinical utility to a certain extent. They can provide a reference basis for the early clinical prevention, diagnosis and treatment of IR in patients with T2DM.
Keywords: Type 2 Diabetes Mellitus Systemic, systemic immune-inflammation index, systemic inflammation response index, Uric acid to HDL-C ratio, Monocyte to HDL-C ratio
Received: 17 Jun 2025; Accepted: 22 Aug 2025.
Copyright: © 2025 He, Sun, Liu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hui Sun, Xi'an Daxing Hospital, Xi'an, China
Jinxia Li, Xi'an International Medical Center Hospital, Xi'an, China
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