ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cancer Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1650314
Insights into Gastric Mixed Adenoneuroendocrine Carcinoma: A Novel Comparative Study of Clinicopathological Features and Survival Outcomes
Provisionally accepted
- 1Taihe Hospital, Hubei University of Medicine, Shiyan, China
- 2Taihe Hospital, Shiyan, China
- 3Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
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Mixed adenoneuroendocrine carcinoma (MANEC) is a rare and histologically complex malignancy. Due to its low incidence, data on gastric MANEC (G-MANEC) are limited, and its clinicopathological characteristics and prognosis remain poorly defined. In this study, we performed a retrospective analysis of 168 G-MANEC patients and identified a median age of 64.7 years at diagnosis. Cases were classified into adenocarcinoma (AC)-predominant and neuroendocrine carcinoma (NEC)-predominant subtypes based on histological composition, with large-cell NEC accounting for 69.9% of NEC-predominant tumors. Patterns of lymph node metastasis (LNM) included involvement of either a single component (AC or NEC) or both components. Survival analysis revealed a median overall survival (OS) of 24 months, with 1-, 3-, and 5-year survival rates of 72.6%, 39.5%, and 29.7%, respectively. Univariate and multivariate analyses identified tumor size, LNM, and histological subtype as independent prognostic factors. Com-pared with a cohort of 328 patients with pure gastric adenocarcinoma, G-MANEC cases exhibited distinct clinicopathological features—particularly in terms of tumor size, Ki-67 index, and LNM. Collectively, these findings underscore that G-MANEC is associated with significantly poorer overall survival than that of conventional gastric adenocarcinoma.
Keywords: gastric, Mixed adenoneuroendocrine carcinomas, prognosis, Risk factors, Clinicopathological characteristics
Received: 19 Jun 2025; Accepted: 22 Aug 2025.
Copyright: © 2025 Huang, Tan, Xiao, HUIMIN, Liu and Di. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jing Huang, Taihe Hospital, Hubei University of Medicine, Shiyan, China
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