REVIEW article
Front. Endocrinol.
Sec. Bone Research
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1653831
This article is part of the Research TopicRecent Advances in the Management of Osteoporosis: Prevention, Diagnosis and TreatmentView all 4 articles
Non-Coding RNAs in osteoarthritis and osteoporosis-related hip fractures: Molecular biomarkers for precision diagnosis and prognosis
Provisionally accepted
- 1Chongqing Medical University, Chongqing, China
- 2The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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As individuals age, bone density declines and the likelihood of fractures increases, particularly in women experiencing menopause. Hip fractures, the most severe consequence of osteoporosis, are becoming more common due to the aging global population and a 1-3% annual increase in hip fractures in most regions. The specific epigenetic mechanisms underlying the onset of osteoporosis and its related fractures remain predominantly unexamined. Research indicates that epigenetic modifications can elevate the risk of osteoarthritis, osteoporosis and bone fractures, especially hip fractures, by linking genetic predispositions with environmental factors. Essential regulatory components in these factors encompass microRNAs, lncRNAs, and circular RNAs. This review examines the function of miRNAs, lncRNAs, and circRNAs in the advancement of osteoporosis, with an emphasis on osteoblasts and osteoclasts. The objective is to enhance comprehension of RNA classes in osteoporotic hip fractures, which may facilitate early detection and prognosis, as well as clarify cellular interactions, potentially resulting in innovative diagnostic techniques and targeted therapies.
Keywords: Hip fracture, Osteoporosis, Osteoarthritis, non-coding RNAs, biomarkers, diagnostics
Received: 26 Jun 2025; Accepted: 16 Sep 2025.
Copyright: © 2025 Zhang, Zhang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jian Zhang, jianzhangjz@proton.me
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