ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Thyroid Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1654110
Lesion Size and Cystic Morphology Are Key Determinants of Parathyroid Hormone Washout in Primary Hyperparathyroidism
Provisionally accepted
- 1Konya City Hospital, Konya, Türkiye
- 2Saglik Bilimleri Universitesi Hamidiye Tip Fakultesi, Üsküdar, Türkiye
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Purpose: Accurate preoperative localization of parathyroid adenomas is of great importance to ensure targeted and effective surgical treatment of primary hyperparathyroidism (PHPT). In this context, parathyroid fine-needle aspiration biopsy (FNAB) performed under ultrasound guidance plays a crucial role. This study aimed to evaluate the relationship between ultrasonographic features of parathyroid adenomas and parathyroid hormone washout (PTH-WO) values.Methods: Between January 2022 and August 2024, data from 128 parathyroid adenomas in 122 patients who were prepared for surgery due to PHPT and underwent ultrasound-guided FNAB along with PTH-WO testing were retrospectively evaluated. The obtained PTH-WO results were compared with B-mode and Doppler ultrasound findings.In adenomas with a long axis greater than 10 mm and those containing cystic components, PTH-WO levels were found to be significantly higher (p = 0.005 and p = 0.02, respectively). Additionally, a positive correlation was identified between PTH-WO levels and the short and long axis dimensions of the adenomas. In contrast, no significant relationship was observed between PTH-WO levels and B-mode (grayscale) or Doppler (vascularity) ultrasound features.PTH-WO values vary according to the ultrasonographic dimensions of parathyroid adenomas and are measured at higher levels in cystic adenomas. Other ultrasonographic features do not significantly affect PTH-WO levels. Therefore, the size of the lesion should be taken into account when interpreting PTH-WO results.
Keywords: 6 Figures: 4 Tables: 5 Total: 9 ( 4 figures, 4 tables, and 1 supplementary table) Primary Hyperparathyroidism, Parathyroid hormone washout, Ultrasonography, Biopsy, Fine-Needle, Parathyroid adenoma, Ectopic tissue
Received: 27 Jun 2025; Accepted: 01 Sep 2025.
Copyright: © 2025 ÇORDAN and Aksu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: iLKER ÇORDAN, Konya City Hospital, Konya, Türkiye
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