CASE REPORT article
Front. Endocrinol.
Sec. Clinical Diabetes
This article is part of the Research TopicThe Need for an Integrative Approach in Type 1 Diabetes ManagementView all 6 articles
Treatment-induced Neuropathy of Diabetes Overlapping With Chronic Inflammatory Demyelinating Polyradiculoneuropathy After Rapid Glycemic Correction: A Case Report
Provisionally accepted
- The Affiliated Hospital of Qingdao University, Qingdao, China
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Treatment-induced neuropathy of diabetes (TIND) often presents with acute-onset neurological symptoms and is frequently underdiagnosed in clinical practice, typically occurring after rapid correction of hyperglycemia. Its coexistence with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) has rarely been reported. As both conditions involve peripheral neuropathy and inflammation, they may share common underlying mechanisms. We report the case of a 26-year-old male patient with type 1 diabetes mellitus (T1DM) who developed TIND followed by CIDP. The patient received insulin pump therapy for glycemic control, along with oral analgesics, including gabapentin and carbamazepine. Targeted treatment for CIDP with methylprednisolone was initiated, leading to improvement in neurological symptoms. Due to persistent severe perineal pain, the patient also underwent interventional pain procedures, including perineal nerve pulsed radiofrequency therapy. Additionally, we review the literature on the pathophysiological mechanisms of TIND and discuss its potential relationship with CIDP, aiming to provide clinical insights that may assist in early recognition and diagnosis. To date, cases of coexisting TIND and CIDP in a single patient have rarely been reported in the literature.
Keywords: Treatment-induced neuropathy of diabetes (TIND), chronic inflammatory demyelinatingpolyradiculoneuropathy (CIDP), Neuropathy pain, T1DM, case report
Received: 27 Jun 2025; Accepted: 30 Oct 2025.
Copyright: © 2025 Hu, Dong, Liu, Deng, Han and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chengqian Li, lichengqian5213@qdu.edu.cn
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