ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Bone Research
The relationship between serum total alkaline phosphatase and risk of osteoporosis: A cross-sectional study
Provisionally accepted
- Chongqing Medical University, Chongqing, China
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Objectives: to extensively investigate the relationship between serum total alkaline phosphatase (ALP) and osteoporosis in a large-scale population. Methods: people who took routine health examinations between 2019 and 2024 at a teaching hospital were included. The health examination records were reviewed, and data were extracted. The variables included anthropomorphic measurements, laboratory tests, and biochemical indices. Osteoporosis was defined by bone mineral density at the spine and hip. The relationship between ALP and osteoporosis was analyzed by using logistic regression, Receiver Operating Characteristic (ROC) analysis, and restricted cubic spline analysis. Results: total ALP in serum was significantly higher in osteoporosis than in non-osteoporosis groups(P<0.001). The relationship between ALP and osteoporosis was persistent in multivariate analysis after adjusting for available confounders. There was a non-linear relationship between ALP and osteoporosis; when ALP was greater than 100 IU/L, the relationship became less pronounced. The relationships between ALP and osteoporosis were stronger in younger, female, and metabolically healthy populations with normal liver enzymes. The best cut-off value for ALP to predict osteoporosis was 72IU/L in ROC analysis. Conclusions: the serum total ALP in serum persistently and negatively relates to the risk of osteoporosis in a general adults population when ALPs are clinic normal. The 72IU/Lof total serum ALP may be considered as a tentative threshold for initiating further bone health counseling in health management for adults. Cohort studies on the application of ALP in the prediction of osteoporosis or osteoporotic fracture are warranted.
Keywords: Osteoporosis, bone turnover, Alkaline Phosphatase, Cross-sectional study, liver enzymes
Received: 01 Jul 2025; Accepted: 24 Nov 2025.
Copyright: © 2025 Chen, Zhang and Nie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yong Zhang, zhangyongcq@live.cn
Mao Nie, 302218@cqmu.edu.cn
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